Expression of Extracellular Matrix Molecules & Receptors during Kidney Development

This table is part of the Kidney Development Database Kidney Development Database

For an explanation of the colunm headings, click here

Extracellular Matrix

Gene/Protein
unind ub
duct tip
duct trunk
unind mm
blastema
cond-s
glom
neph
stroma
Remarks
References
Collagen 1 protein
n
n
n
Y
Y
n
n
n
?
-
Ekbolm 1981

Collagen III protein

n
n
n
Y
Y
n
n
n
?
-
Ekblom 1981
Collagen IV RNA
-
-
Y
n
-
Y
Y early
Y
-
-
Laurie 1989
Collagen IV protein
Y
?
Y
n
n
Y
Y
Y
Y
-
Ekblom 1981
Collagen V protein
-
-
-
n
n
Y
-
Y
-
-
Bonadio 1984
Collagen XVIII
-
-
-
n
n
?Y
Y
Y
n
chick data
Halfter 1998
Collagenase type IV
(72KD)
-
-
-
-
Y
-
-
-
-
-
Reponen 1992
Fibronectin
n
n
n
ectodomain A+, B+ (in bm)
Y
ectodomain A+, B+
Y
n
n
ecto B+ briefly Onc-cFN + mesang
n
ecto A+
n
ecto A
-
Ekblom 1981
Laitinen 1991
Flexilin
-
-
-
-
-
-
Y
-
-
bovine
Lethias 1996
Laminin B RNA
(beta1)
-
-
Y
n
-
Y
Y early
Y
-
-
Laurie 1989
Laminin B protein
(beta1)
Y
Y
Y
(y)
(y)
Y
Y
Y
?
-
Ekblom 1980
Virtanen 1995

Bernardini 1999 (human) 
Laminin A RNA
(alpha1)
?
Y
(y)
n
n
Y
goes
goes
n
-
Ekblom 1990
Virtanen 1995
Laminin A Protein
(alpha1)
?
?
?
n
n
Y
Y
Y
n
decays
Sorokin 1990 
Laminin gamma 1
?
Y
Y
n
n
Y
Y
Y
n
human
Virtanen 1995 
Nidogen
Y
Y
Y
(y)
y
around not in
-
Y
n
LN-nidogen binding req'd for devpt 
Ekblom 1994
NOF
?
Y
Y
?
n
Y
when polar
Y
Y
n
chick data
Takaha 95
Osteonectin
?
?
?
?
?
?
?
Y
?n
-
Kopp 1992
Tenascin
n
n
n
n
n
n
n
n
Y
-
Aufderheide 1987
Tubulointerstititial
antigen
n
n
n
n
n
distal pole of S
n
distal
n
-
Kanwar 1999
Protease nexin I
somewhere in the developing kidney (Northern blot data)

Mansuy 1993
Gene/Protein
unind ub
duct tip
duct trunk
unind mm
blastema
cond-s
glom
neph
stroma
Remarks
References

GENES/PROTEINS NOT EXPRESSED

Gene/Protein
References
Laminin alpha 3 (human) Virtanen 1995
Laminin beta 3 (human) Virtanen 1995
Laminin-5 (kalinin) human Virtanen 1995

 

Matrix Receptor Expression

NB - molecules that are both cell-cell and cell matrix receptors may be listed in the CAM table.

Gene
unind ub
duct tip
duct trunk
unind mm
blastema
cond-s
glom
neph
stroma
Remarks
References
Dystroglycan-alpha 1
-
-
-
n
n
y
epithelial
-
Y
n
-
Durbeej 1995
Galectin 3 (Mac2)
-
-
Y
-
-
Y
N
Y distal
n
-
Winyared 1997
Integrin-alpha 1
?
n
n
Y
-
goes
mesang
n
Y some
human data
Korhonen 1990, 1992
Integrin-alpha 2
?
Y
Y cortex
n
n
n
endoth
Y distal
n
human data
Korhonen 1990, 1992
Integrin-alpha 3
n
n
n
n
n
n
Y
n
n
human data
Korhonen 1990 & 1992
Integrin-alpha 5
expressed in endothelia only
human data
Korhonen 1990 & 1992
Integrin-alpha 6
Y
Y
Y
n
?n
Y
?Y
Y
n
human data
see modifier table
under anti-laminin,
and mutant table
Sorokin 1990
Korhonen 1990 & 1992
Integrin-alpha 8
n
n
n
n
?y
Y
condensates
n
n

Y

see mutant tables
Muller 1997
Integrin-beta 1
Y
Y
Y
Y
Y
Y
Y
Y
Y
human data
Korhonen 1990 & 1992
Bernardini 1999 (human)
Integrin-beta 4
?Y
Y
Y
n
n
n
n
n
n
human data
Korhonen 1990 & 1992
Laminin receptor
67/32-kD
-
-
Y
n
?
Y
Y
early
Y
-
-
Laurie 1989
L14 lectin
-
-
-
Y
Y
-
-
-
Y
-
Poirier 1992

GENES NOT EXPRESSED

Gene
References
Integrin-alpha 4 Korhonen 1990

Proteoglycans

These may also appear in the functionally-arranged tables above, but are set out in their own table below as well, because it can be difficult to place a proteoglycan in a single functional table.

Gene/Protein
unind ub duct tip duct trunk unind mm blastema cond-s glom neph stroma Remarks
References
Dystroglycan-alpha 1
-
-
-
n
n
y
epithelial
-
Y
n
- Durbeej 1995
MUC-1
?y
Y
Y
n
n
n
n
n
n
  Chambers 1994
Syndecan 1 protein
Y
Y
Y
(y)
y
Y
goes
goes
n
  Vainio 1992
Syndecan 1 RNA
-
-
-
(y)
y
Y
goes
goes
n
rises after protein
Vainio 1992
Syndecan 2 (fibroglycan)
n
n
n
Y
Y
n
n
n
?y
  David 1993

GENES/PROTEINS NOT EXPRESSED

Gene/Protein
References
MUC-2 Chambers 1994

Date of last revision: January 2006
Comments about the database are always welcome.
Email: Jamie.Davies@ed.ac.uk