Expression of Signaling Molecules & Receptors in Pronephric and Mesonephric Development

Part of the Kidney Development Database.
For an explanation of the colunm headings, click here.

Growth Factors & other Signalling Molecules (Wnts listed separately below)

Gene
pro prim
pro tub
pro glom
pro duct
meso mes
meso tub
meso glom
WD
organism
comments
References
Bhh
(banded hedgehog)
-
Y
-
-
-
-
-
-
xenopus
homologue of Indian hedgehog
Ekker 1995
BMP-7
-
-
-
-
?
y
-
y
mouse E9.5

Lyons1995
FGF-2
-
y
-
y
?
y
y
?
chick st24
1st seen in intermed mesoderm
Dono 1994
Savage 1995
Zuniga Mejia Borja 1996
FGF-8
-
-
-
-
-
-
-
n (chick)
y (mouse)
y (chick)
n (mouse)
n (chick)
?
-
-
n (chick)
mouse E9.5
chick st13
-
Crossley 1995
Crossley 1996
Vogel 1996
Follistatin
y (xen)
y (xen)
-
n (xen)
-
-
-
-
xenopus st24
also mouse E9.5 ventrolateral cells
Hemmati-Brivanlou 1994
Albano 1994
Feijen 1994
HGF
-
-
-
-
-
-
-
-
y (chick)
y (mouse)
-
n (mouse)
-
n (mouse)
-
n (mouse)
chick st17
mouse E10
also in xenopus vent mes st14
Myokai 1995
Sonnenberg 1993
Nakamura 1995
Inhibin a
-
-
-
-
-
-
-
-
-
-
n (chick)
n (mouse)
y ( chick)
? (mouse)
? (chick)
n (mouse)
chick st24
mouse E12.5
-
Blauer 1992
Feijen 1994
Star-1
expressed somewhere in mesonephros (v low mag pictures)
mouse
-
Bouillet 95

 

Wnt Genes

Gene
pro prim
pro tub
pro glom
pro duct
meso m
meso tub
meso glom
WD
organism
comments
References
Wnt-4 y
(Xwnt4 in Xenopus)
y (xen)
y (zfish)
-
-
n (xen, mouse, chick, zfish)
y (mouse, chick, xen)
y (mouse, chick)
-
y (mouse, chick)
xenopus st25
mouse E9.5
chick st20
zebrafish 13h
-
McGrew 1992
Moon 1993
Parr 1993
Stark 1994
Yoshioka 1994
Ungar 1995
Wnt-11
-
-
-
-
n
-
-
y
mouse E9
-
Kispert 1996

 

Peptide Hormones

Gene
pro prim
pro tub
pro glom
pro duct
meso m
meso tub
meso glom
WD
organism
comments
References
angiotensinogen
-
-
-
-
-
y (prox)
most but not all
-
-
sheep 41days (not 27 )
-
Wintour 1996
renin
-
-
-
-
-
y (prox)
-
-
sheep 41days (not 27 )
also seen in blood vessel walls
Wintour 1996

 

Receptor Kinases

Gene
pro prim
pro tub
pro glom
pro duct
meso m
meso tub
meso glom
WD
organism
comments
References
EBK / MDK1
-
y
-
?
?
-
?
y
mouse E11.5
-
Ciossek 1995
Ellis 1995
FGFR1 (flg)
-
-
-
-
y
y
-
-
mouse E9.5
-
Orr-Urtreger 1991
FGFR2 (bek)
-
-
-
-
y
y
-
-
mouse E9.5
-
Orr-Urtreger 1991
KGFR
-
-
-
-
y
y
-
-
mouse E10.5
splice var of FGFR2
Orr-Urtreger 1993
FGFR4
(PFR-4)
-
? (zfsh)
-
y (newt)
y (zfsh)
-
-
-
-
newt st38
zebrafish 11h
-
Launay 1994
Thisse 1995
E7/G62
-
y
-
y
-
-
-
-
xenopus
FGFR4 related
Brandli 1995
FREK
-
-
-
-
-
y
-
-
chick st23
FGFR4 related
Marcelle 1994
Pagliaccio
-
y
-
-
-
-
-
-
xenopus st26
? = mouse SEK1
Winning 1994
c-met
-
-
-
-
n
y
n
y
?mouse E11
-
Sonnenberg 1993
c-Ret
n (chk 10)

? (mouse)
n (zfish)
? (chk 10)

? (mouse)
? (zfish)
n (chk 10)
y (chk 10)

y (mouse)
y (zfish)
n (chk)
n (chk)
n (mouse)
y (chk10)
y (chk 24)
y (mouse)
n (chk10)
y (chk10)
y (chk)
y (mouse)
chick st10
chick st24
mouse E8.5
zebrafish 10h
-
Schuchardt 1995
Schuchardt 1995
Pachnis 1993
Marcos-Gutierrez 1997
c-ros

-
n (mouse)
-
n (mouse)
-
n (mouse)
-
n (mouse)
-
n (mouse)
-
-
n (mouse)
y (chk)
n (mouse)
chick st33
mouseE10.5
-
Chen 1994
Sonnenberg 1991
Tessarolo 1992
trk C
-
-
-
-
y (mouse)
y (chick)
-
-
-
mouse E11.5
chick
-
Tessarolo 1993
Kahane & Kalcheim 1994
XFGFR1a
-
y
-
y
-
-
-
-
xenopus
-
Brandli 1995
Gene
pro prim
pro tub
pro glom
pro duct
meso m
meso tub
meso glom
WD
organism
comments
References

 

Nuclear Hormone Receptors

Gene
pro prim
pro tub
pro glom
pro duct
meso m
meso tub
meso glom
WD
organism
comments
References
HNF-4
n
?
-
n
n
y
-
n
mouse E10.5
-
Duncan 1994
Taraviras 1994
HNF-4a
n
y
-
n
-
-
-
-
xenopus st 29
once named HNF4
Holewa 1996 & 1997
RAR-a
(RARa2.1/2.2 for Xenopus)
-
n (Xen)
-
n (Xen)
-
-
y (mouse)
n (xen)
y (mouse)
-
?y (mouse)
mouse E10.5
xenopus
-
Dolle 1990
Sharpe 1992
RAR-b
-
-
-
-
y
y
?
y
mouse E10.5
-
Dolle 1990
CRABP-I
-
-
-
-
y
n
-
n
mouse E10.5
seen early in lateral
Ruberte 1992
Dolle 1990

 


Miscellaneous Signalling Molecules

Gene
pro prim
pro tub
pro glom
pro duct
meso m
meso tub
meso glom
WD
organism
comments
References
calbindin D-28k
-
-
-
-
-
y connecting
segment
-
y
mouse E11
click for micrograph
Davies 1994
Shamley 1992
a-catenin
y
-
?
-
-
-
-
-
xenopus st27
-
Fagoto 1994
p75-NGFR
-
-
-
-
n
y
y
y
rat E11
-
Sainio 1997
Notch
-
-
-
-
-
y
-
-
mouse E9
-
del Amo 1992
Reaume 1992

Date of last revision: January 2006
Comments about the database are always welcome.
Email: Jamie.Davies@ed.ac.uk