Expression of Transcription Factors in Pronephric & Mesonephric Development.

Part of the Kidney Development Database.
For an explanation of the colunm headings, click here.

Hox Genes

Gene
pro prim
pro tub
pro glom
pro duct
meso m
meso tub
meso glom
WD
organism
comments
References
Hox A3 (1.5)
-
-
-
-
-
y
?y
?y
mouse E12.5
diffuse stain
Gaunt 1988
Hox A4 (1.4)
-
-
-
-
-
y
?y
?y
mouse E12.5
diffuse stain
Gaunt 1988
Hox A5 (1.3)
-
-
-
-
-
y
?y
?y
mouse E12.5
diffuse stain
Gaunt 1988
Dressler 1989
Hox A6 (1.2)
-
-
-
-
-
y
?y
?y
mouse E12.5
diffuse stain
Gaunt 1988
Dressler 1989
Hox A7 (1.1)
-
-
-
-
-
y
?y
?y
mouse E12.5
diffuse stain
Dressler 1989
Hox A10
-
-
-
-
Y
n
n
?
mouse E12.5
-
Benson 1995
Hox A11
-
-
-
-
Y
n
n
n
mouse E14
-
Hseih-Li1995
Hox B4 (2.6)
(Xhox 1.4)
-
n (xen)
-
n (xen)
-
-
y (xen)
-
y (mouse)
-
?y (mouse)
-
?y (mouse)
-
mouse E12.5
xenopus
diffuse stain
Gaunt 1988
A Durston (pers comm)
Hox B5 (2.1)
(Xhox1B)
-
n (xen)
-
n (xen)
-
-
-
y (xen)
?y (mouse)
-
y (mouse)
-
-
-
?y (mouse)
-
mouse E12.5
xenopus
-
Holland 1988
Hogan 1988
Wall 1992
A Durston (pers comm)
Hox B7 (2.3)
-
-
-
-
y
y
-
?y
mouse E9.5
-
Vogels 1990
Kress 1990
Hox B9 (2.5)
-
-
-
-
-
y
-
-
mouse E9.5
-
Bogarad 1989
Hox C6 (3.3/6.1)                
mouse E12.5
diffuse stain
Gaunt 1988
Hox C8 (3.1)
-
-
-
-
-
y
?
?
mouse E12.5
diffuse stain
Gaunt 1988
Gaunt 1988
Dressler 1989
Hox C9 (3.2)
-
-
-
-
-
?
-
-
mouse
-
Erselius 1990
Hox D4 (4.2/5.1)
-
-
-
-
n
y
?
?
mouse E12.5
-
Gaunt 1989
Izpisua-Belmonte 1990
Hox D8 (4.3/5.4)
-
-
-
-
n
y
-
?
mouse E10.5
-
Izpisua-Belmonte 1990
Hox D9 (4.4/5.2)
-
-
-
-
n
y
-
?
mouse E10.5
?marks genital tubule progenitors
Izpisua-Belmonte 1990
Dolle 1989
Hox D10 (4.5/5.3)
-
-
-
-
n
?
-
?
mouse E10.5
-
Dolle 1989
Gene
pro prim
pro tub
pro glom
pro duct
meso m
meso tub
meso glom
WD
organism
comments
References

 

Pax Genes

Gene
pro prim
pro tub
pro glom
pro duct
meso m
meso tub
meso glom
WD
organism
comments
References

Pax 2

 

X-Pax2

y

 

-

y

 

y

-

 

-

y

 

n

y

 

-

y

 

-

n

 

-

y

 

-

mouse E9

 

xenopus st21

see mutant table

 

-

Phelps 1993
Dressler 1990
Asano 1992
Puschel 1992
Heller & Brandli (pers comm)
Pax [zf-b]
y
y
n
y
-
-
-
y
zebrafish 15h
-
Krauss 1991 & 1992
Puschel 1992
Pax-8
-
y
-
n
y
y
n
n
mouse E9
-
Plachov 1990
Asano 1992

 

HMG & other Hox-like Genes

Gene
pro prim
pro tub
pro glom
pro duct
meso m
meso tub
meso glom
WD
organism
comments
References
Emx-1
-
-
-
-
-
y
-
-
mouse E9.5
-
Briata 1996
engrailed -1
n
y
n
n
-
-
-
-
xenopus st35
-
Eizema1994
LFB-1
(HNF1a)
-
-
-
? (xen)
-
-
n (mouse)
-
n (mouse)
-
-
-
n (mouse)
xenopus st35
mouse E9.5
-
Bartowski 1993
Ott 1991
Lazarro 1992
Cereghini 1992
Blumenfeld 1991
LFB-3
(HNF1b/vHNF1)
y (xen)
y (xen)
-
y (xen)
n (xen)
y (xen)
y (mouse)
-
y (xen)
y (mouse)
xenopus st16
mouse E12.5
v early pronephros
marker in xenopus
Demartis 1994
De Simone 1991
Cereghini 1992
Ott 1991
LIM-1
y (xen)
-
y (xen)
-
-
y (xen)
-
-
y (mouse)
-
y (mouse)
-
-
y (mouse)
xenopus st17/18
mouse E8.5
v early pronephros marker
Taira 1992 & 1994
Barnes 1994
Fujii 1994
Six-2

-
y
-
-
-
y early, later in
stroma
-
-
mouse
low resoluton images
Oliver 1995
XDCoH
y
y
?
n
-
-
-
-
xenopus st25/26
-
Pogge 1995
XEmx-1
y
-
-
y
-
-
-
-
xenopus st21/22
-
Pannese 1998

 

Zinc Finger Genes

(allig)
Gene
pro prim
pro tub
pro glom
pro duct
meso m
meso tub
meso glom
WD
organism
comments
References
Brca 1
-
-
-
-
n
Y
-
-
mouse
-
Lane 1994
WT-1

y (xen)
y (mouse)
-

 

n (chick)
-

n (xen)
n (mouse)
-

 

? (chick)
-

y (xen)
y (mouse)
-

 

-
-

n (xen)
n (mouse)
-

 

n (chick)
n (allig)

-
y (mouse)
y (man)

 

y (chick)
y (allig)

-
n (mouse)
n (man)

 

? (chick)
? (allig)

-
y (mouse)
y (man)

 

y (chick)
y (allig)

-
n (mouse)
n (man)

 

n (chick)
n (allig)

xenopus st25
mouse E9.5
human 34dpc

 

chick st16
alligator st6

splanchnic mesoderm (xen)
Carroll 1996
Pritchard-Jones 1990
Kreidberg 1993
Rackley 1993
Armstrong 1993
Mundlos 1993
Kent 1995
Kent 1995
Gli
-
-
-
-
y
?
-
n
mouse E11.5
-
Hui 1994
Gli-2
-
-
-
-
y
?
-
n
mouse E11.5
-
Hui 1994
Gli-3
-
-
-
-
y
?
-
n
mouse E11.5
-
Hui 1994
Xsal-1
-
y
-
y
-
-
-
-
xenopus st 31
-
Hollemann 1996

 


Fork-head Genes

Gene
pro prim
pro tub
pro glom
pro duct
meso m
meso tub
meso glom
WD
organism
comments
References
XFD-4
-
y
-
y
-
-
-
-
xenopus st 24
related to MFH-1/FKH1
Scheucher 1995
Lef 1996
XFD-7/7 (XFKH-2)
n
y
-
y
-
-
-
-
xenopus st 35
ortholog of HNF-3a
Lef 1996
XFD-9
n
n
-
?
-
-
-
-
xenopus st 25
related to HFH-B2
Scheucher 1995
Lef 1996
MF1
-
?
-
?
-
-
-
?
mouse E8.5
lateral mesoderm
Sasaki1993
MF2
?
-
-
?
-
-
-
?
mouse E8.5

Sasaki1993

 

Ets Genes

Gene
pro prim
pro tub
pro glom
pro duct
meso m
meso tub
meso glom
WD
organism
comments
References
ets-2
n
y
-
y
-
-
-
-
xenopus st26/27
-
Pierre Remy (pers comm)
Xl-Fli
y
y
-
y
-
-
-
-
xenopus st17
-
Meyer 1995

 


Miscellaneous Nuclear Proteins

Gene
pro prim
pro tub
pro glom
pro duct
meso m
meso tub
meso glom
WD
organism
comments
References
GATA-2
n
n
-
n (see comments)
-
-
-
-
xenopus st23/2
in haematopoetic precursors near pronephric duct
Bertwistle 1996
GATA-3
n (xen)
n (zfish)
n (xen)
n (zfish)
-
-
n (xen))
y (zfish)
-
-
-
-
y (mouse)
-
-
-
y (man)
-
-
-
y (man)
xenopus st24
zebrafish 13h
mouse E10.5
human
in xenopus it is seen in haematopoetic precursors near pronephric duct
George 1994
Neave 1995
Labastie 1995
Bertwistle 1996
ld (formins)
?
y
?
y
-
y
y
y
chick st14
-
Trumpp 1992
L-myc
-
-
-
-
-
-
-
?
mouse E10
-
Mugrauer 1991
N-myc
y
y
-
n
y
y
-
?
mouse E9.5
see mutant table
Stanton 1992
Charron 1992
Kato 1991
XlPou2
-
y
-
?
-
-
-
-
xenopus st24
related to mammal Brn-4/RHS2
Witta 1995

Date of last revision: January 2006
Comments about the database are always welcome.
Email: Jamie.Davies@ed.ac.uk