Expression of Signalling Molecules during Kidney Development

This table is part of the Kidney Development Database

For an explanation of the colunm headings, click here

Growth Factors and similar but not Wnts.

Gene
unind ub duct tip duct trunk unind mm blastema cond-s glom neph stroma Remarks
References
Activin-beta-a
-
-
n

-
-
?y
n
n
n
cortex only
Roberts (94)
says absent in rat kidney;
see modifier table
Ritvos 1995
B61
(ECK ligand)
n
n
n
scattered
cells only
-
Y
Y
+ endoth

early
(no info for later)

n
-
Takahashi 1995
BMP2
-
-
-
-
-
?Y
-
-
n
v low power
Lyon 1995
BMP4
n
n
n
n
n
y
n
n
y
-
Miyazaki 2000
BMP5
n
n
Y pelvis
n
n
n
n
n
n
-
King 1994
Bmp7
-
-

Y (Godin)

y (Lyons)
y goes later (Vukic..)
Y (Godin & Vukic..)

y (Lyons)
y goes later (Vukic..)
Y (Godin & Vukic..)
-
n

-
Y
?

-
Y
Y

-
-
Y

-
lost
?Y

-
n
n

-
see mutant table
see modifier table
see inducer table
Lyons 1995
Vukiceric et al 1996
Godin 1998
Dll1
-
-
-
-
-
-
Y
y
-
-
McCright 2001
Dll4
-
-
-
-
-
-
Y
y
-
-
McCright 2001
FGF2 (bFGF)
-
Y
Y
-
-
y
nuclear in podocytes
y
-
chicken data
Dono 1994
FGF7
-
-
-
-
-
-
-
-
y
-
Qiao 1999
FGF8
-
-
-
-
-
-
y
-
-
-
Mahmood 1995
FGF12
-
n
n
n
n
n
y
n
n
-
Hartung 1997
FGF13
-
n
n
n
n
n
n
n
y

Hartung 1997
Epimorphin
-
-
-
?Y
?Y
-
-
-
?

Hirai 1992
Fas ligand
-
-
-
-
-
-
-
-
-
acquired by late devpt
Suda 1993
Follistatin
-
-
-
-
?Y
-
-
-
cortex only
-
Ritvos 1995
Roberts 1994
GDNF
n
n
n
Y
Y
-
-
-
-
see mutant table & modifier table
Trupp 1995
Sanchez 1996
Pichel 1996
Sainio 1997
HB-GAM
-
Y
Y
-
-
-
-
Y
-
-
Mitsiadis 1995
HDGF
y
Y
Y
y
Y
Y
Y
Y
?
-
Oliver 1998
HGF
?
n
n
?
Y
n
n
n
?
anti-HGF blocks ub devpt & nephrogenesis;
transgenic KO no effect.
Sonnenberg 1993
Woolf 1995
Birchmeier W (pers comm)
IGFI
n
n
n
n
n
n
n
Y
-
see mutant table
Matsell 1993
IGFII
-
-
-
Y
Y
Y
Y
-
-
see mutant table
Matsell 1993
Jag1
n
n
n
n
Y
Y
Y
n
-
see mutant table
McCright 2001
Midkine -

-
Y

-
Y

-
-

-
y

Y
y

Y
-

Y
Y

-
-

-


retinoic acid senisitve; antibodies inhibit devpt
Mitsiadis 1995, a & b

Vilar 2002
NTN (neurturin)
-
Y
Y
n
n
n
-
-
-
-
Widenfalk 1997
NT-3
mRNA expressed somwhere in developing kidney
see modifier table
Karavanov 1995
PDGF A
n
y weak
n
n
n
y
mesangium
Henle
n
-
Seifert 1998
PDGF B
n
n
n
?
n
n (Lindah)
y (Seifert)
vasc endoth, mesangium
n
n
see mutant table
Lindahl 1998
Seifert 1998
Pleiotrophin
-
-
-
-
Y
-
-
-
-
-
Sakurai 2001
TGF-alpha
?
y
y
?
y
?y
-
-
-
-
Bernardini 2001
TGF-B1 RNA
?
n
n
?
n
n
n
n
?Y
KO no effect
Lehnert 1988
Boivin 1995
TGF-B1 protein
n
n
n
(n)
(n)
n
n
n
?Y
data from low res fig - authors make no claim in text about kidney
Heine 1987
VEGF
-
-
-
-
n
n
Y
(n)
-

Breier 1992
Gene
unind ub
duct tip
duct trunk
unind mm
blastema
cond-s
glom
neph
stroma
Remarks
Reference

GENES NOT EXPRESSED

Gene
References
Activin-alpha Roberts 1994 (rat)
Activin-beta-b Roberts 1994 (rat)
FGF7 Mason 1994
FGF8 Heikinheimo 1994

Wnt Gene Expression

Gene
unind ub duct tip duct trunk unind mm blastema cond-s glom neph stroma Remarks
References
Wnt 4
-
n
n
n
?
Y
n
lost after fusion
n
required for epithelialisation:
seems to auto- activate
Stark 1994
Wnt 5b
y
y
y
y
y
y
y
y
y
uniform
Gavin 1990
Wnt 7b
-
     (y)
Y
-
-
-
-
-
-

Carroll 2005
Wnt 9b

    weak
          Y






can induce nephrogenesis
Carroll 2005
Wnt 11
-
Y
v weak
-
-
-
-
-
-
human
Lako 1998

Wnt GENES NOT EXPRESSED

Gene
References
Wnt 1 Wilkinson 1987
Wnt 3 Roelink 1991 *
Wnt 3a Roelink 1991 *
Wnt 5a Roelink 1991 *
Wnt 12 Christiansen 1995

* Note: this paper does not actually say Wnt (n) is not expressed in kidney; but kidney does not appear in the long list of expressing tissues.

 

Hormones

Gene
unind ub duct tip duct trunk unind mm blastema cond-s glom neph stroma Remarks
References
angiotensinogen
-
-
Y
-
-
-
-
only a few proximal cells
-
sheep E41
Wintour 1996
Prieto 2001
renin
found in the walls of arteries close to the hilus, in E41 (but not E27) day sheep embryos; later a marker for juxtaglomerular apparatus
sheep E41
mouse E14.5
Wintour 1996
Jones 1990
stanniocalcin
-
-
sequester then express
Y
Y
n
n
sequester later
-
complex! - see the paper
Stasko 2001

Second Messenger Mediators

Gene
unind ub duct tip duct trunk unind mm blastema cond-s glom neph stroma Remarks
References
14-3-3 epsilon
?
n
n
?
Y
Y
n
n
n
-
McConnell 1995
SET
?
n
n
?
Y
Y
n
n
n
-
Kim 1994
CaBP 9kD
?
?
Y
n
n
n
?
Y
-
-
Shamley 1992
CaBP 28kD
Y
Y
Y
n
n
n
n
distal
n
vitD dependent in nephron
Davies 1994
Dvl-1
expressed apparently ubiquitously throughout urogenital system (& elsewhere)
-
Sussman 19 94
bcl-xl
shown to be present somewhere by S1 nuclease protection assay
-
Gonzalez-Garcia 1994
bcl-2
n
-
-
?
n
Y
(y)
proximal

human data
LeBrun 1993
I-1
-
n
n
-
Y
n
n
n
n
inhibitor of protein phosphatases
Svennilson 1995
Protein phosphatase 1
all isoforms expressed ubiquitously in 15 day kidneys
rat data
Svennilson 1995
Protein phosphatase 2A
all isoforms expressed ubiquitously in 15 day kidneys
rat data
Svennilson 1995
Smad-1
-
-
-
(n)
Y
n
Y
Y
Y
-
Oxburgh 02
Smad-2
-
-
Y late
?
Y
n
Y
Y
Y
-
Oxburgh 02
Smad-3
-
Y
Y
?
Y
n
(y)
(y)
(y)
-
Oxburgh 02
Smad-4
-
-
Y late
?
Y
n
Y
Y
Y
-
Oxburgh2002
Smad-5
-
-
-
?
Y
n
n
n
-
-
Oxburgh 02
Smad-8


?
Y
n
n
n
-
-
Oxburgh 02
mTim
?
Y
?
(n)
(n)
y
-
-
-
rat data
Li 2000
Gene
unind ub duct tip duct trunk unind mm blastema cond-s glom neph stroma Remarks
References

SECOND MESSENGER MEDIATOR GENES NOT EXPRESSED

Gene
Reference
bcl-xs Gonzalez-Garcia 1994  

Date of last revision: January 2006
Comments about the database are always welcome.
Email: Jamie.Davies@ed.ac.uk