Expression of Signal Molecule Receptors & Signal Transduction Molecules during Kidney development

This table is part of the Kidney Development Database.
For an explanation of the column headings click here.

Gene
unind ub duct tip duct trunk unind mm blastema cond-s glom neph stroma
Remarks
References
Activin Y receptor
II,IIB
-
-
-
-
-
?Y
?
?Y
-
low power;
Roberts 1994
says ActRII not in rat
Manova 1995
Alk3
"almost ubiquitous"
-
Miyazaki 2000
Alk6
Y
Y
Y
n
n
n
n
n
n
-
Miyazaki 2000
BMPR-IA
-
Y
Y
n
Y
Y
n
n
-
-
Martinez 2001
BMPR-IB
-
Y
Y
n
Y
Y
n
n
-
-
Martinez 2001
BMPR-II
-
Y
n
n
Y
Y
n
n
-
-
Martinez 2001
EGFR
Y
Y
Y
n
?Y
n
n
n
Y
assay by hot EGF binding
Partanen 1987
ECK
strong cortical staining in E15 murine kidney
v low power
Mori 1995
EGFR
Y
Y
Y
n
?Y
n
n
n
Y
assay by hot EGF binding
Partanen 1987
FGFR bek
Y
Y
Y
?
n
-
-
-
-
-
Orr-Urtreger 1991
FGFR flg
n
?n
?n
?
Y
Y
Y
y less later
n
-
Orr-Urtreger 1991
Frzb-1
somewhere in maturing kidney (Northern data)
-
Leyns 1997
GFR-a1
Y
y
y
?
Y
Y
-
-
y
-
Sainio 1997
GFR-a2
n
n
n
n
n
n
n
n
pelvic
-
Wildenfalk 1997
GFR-a3
cortex of foetal kidneys (low power micrographs)
-
Naveilhan 1998
GFR-a4
?
?
?
-
-
Y(S)
Y
Y
pelvic
-
Alun Davies
St Andrews Uni
(pers comm)
Grb-7
?
Y
Y
n
n
Y(S)
(n)
Y
n
-
Leavey 1998
IGFBP2
Y
n
n
?
Y
Y
Y
Y
?
-
Matsell 1993
IGFBP3
n
Y
Y
n
n
n
n
n
-
-
Matsell 1993
IGFBP4
n
n
n
?
Y
?n
Y
Y
-
-
Matsell 1993
IGFBP5
-
-
-
-
-
n
Y
-
-
-
Matsell 1993
IGFBP6
-
-
-
-
-
Y
n
-
-
-
Matsell 1993
IGFI-R
-
-
-
-
-
-
-
y
-
antisense reduces
ub & neph devpt
Wada1993
Liu 1993
MDK-1
?
Y
Y
-
-
-
-
-
-
-
Ciossek 1995
MeL1a
melatonin receptor
?
-
-
n
n
Y
?
early
-
-
Drew 1998
KGF-R
?
Y
Y
-
-
-
-
-
-
-
Qiao 1999
MDK-1
?
Y
Y
-
-
-
-
-
-
-
Ciossek 1995
Notch 1
?
?
?
?
?
?Y
Y
?
n
rat data
Weinmaster 1991
Notch 2
?
Y
Y
?
n
Y
Y
n
n
-
Weinmaster 1992
McCright 2001
Nov
expressed somewhere in foetal kidney during development
see Wilms data
Martinerie 1996
P2X (7)
-
-
-
-
-
Y
-
-
-

Hillman 2002
p75 NGFR
n
n
n
-
Y
Y
Y
decays when mature
n
y
antisense
blocks devpt.
transgenic KO no effect.
Durbeej 1993
Sariola 1991
Lee 1992
Met
?
Y
Y
y
(Woolf)
Y
(Woolf)
Y
n
Y
n
-
Sonnenberg 1993
Woolf 1995
PDGF-R alpha
n
n
n
-
y
-
-
-
Y
perivasc mesenchyme
Shinbrot 1994
Lindahl 1998
Seifert 1998
PDGF-R beta
n
n
n
-
y
-
-
-
-
-
Seifert 1998
RAR-alpha
-
-
-
-
?y
-
-
-
Y
see mutant table
Dolle 1990
Mendelsohn 1999
RAR-beta
-
-
-
-
-
-
-
-
y
see mutant table
Dolle 1990
Mendelsohn 1999
RAR-gamma
-
n
n
-
n
n
n
n
n
see mutant table
Dolle 1990
sFRP1
-
-
-
?
Y
Y
n
Y
esp Henle
n
Y(rat)
-
Leimeister 1998
Yoshino 2001
sFRP2
-
-
-
?
Y
Y
Y
goes
n
-
Leimeister 1998
sFRP4
-
-
-
n
n
y
n
n
n
-
Leimeister 1998
CRABP
-
-
-
-
Y
?Y
-
-
-
low mag pics
KO no effect
Dolle 1990
de Bruijn 1994
CRBP
-
-
-
-
-
?y
y
n
n
-
Dolle 1990
c-ret
Y
Y
n
n
n
n
n
n
n
KO kills ub depvt
Pachnis 1993, 1994
c-ros
Y
Y
n
n
n
n
n
n
n
-
Tessarollo 1992
c-ron
weak cortical signal in E14.5; associated with epithelia but unclear which ones
  Gaudino 1995
CD71 transferrin receptor
-
-
-
-
n
Y
y
y
n
human data.
mouse kidneys need transferrin.
Fleming 1987
trkB
-
-
-
-
Y
-
-
-
?Y
active & truncated
Durbeej 1993
trkC
-
-
Y
-
-
-
-
-
-
-
Durbeej 1993
Gene
unind ub
duct tip
duct trunk
unind mm
blastema
cond-s
glom
neph
stroma
Remarks
References

GENES NOT EXPRESSED

Gene
References
FGFR type 3 Peters 1993

Date of last revision: January 2006
Comments about the database are always welcome.
Email: Jamie.Davies@ed.ac.uk