Expression of Transcription Factors during Kidney Development

This table is part of the Kidney Development Database

For an explanation of the colunm headings, click here

Hox Genes

(Note: for more details on general properties of Hox genes, visit "The Homeobox Page")

Gene
unind ub duct tip duct trunk unind mm blastema cond-s glom neph stroma Remarks
References
Hox A3 (1.5)
?
Y
Y
?
Y
?
?
?
?
-
Gaunt 1987,1988
Hox A4 (1.3)
?
Y
Y
?
Y
?
?
?
?
-
Gaunt 1988
Hox A5 (1.3)
?
Y
Y
?
Y
?
?
?
?
-
Gaunt 1988
Hox 6 (1.2)
?
Y
Y
?
Y
?
?
?
?
-
Gaunt 1988
Hox A7
seen in the cortex of foetal kidneys
-
Knittel 1995
Hox A11
-
-
-
-
Y
-
-
-
-
see mutant table
Hsieh-Li 1995
Hox B3 (2.7)
?
Y
Y
?
n
Y
Y
Y
n
-
Kress 1990
Hox B7 (2.3)
n
Y
Y
n
n
Y
Y
?
?
1316bp cis regulatory seq
can target reporter genes
Vogels 1990
Kress 1990
Hox B4 (2.6)
detected somewher in the kidney (Northern blot data)
-
Graham 1988
Hox B5
?
Y
Y
?
Y
Y
?
Y
n
-
Holland 1988
Hogan 1988
Wall 1991 & 1992
Hox C6 (6.1)
?
Y
Y
?
Y
?
?
?
?
-
Sharpe 1988
Hox C8 (3.1)
?
Y
Y
?
Y
?
?
?
?
-
Gaunt 1988
Hox C9 (3.2)
n
n
n
n
Y
Y
n
Y
n
KO no effect on kidneys
Erselius 1990
Suemori 1995
Hox 5.2
-
?Y
Y
-
y
y
-
y
?y
low power
Dolle 1989
Hox 5.3
-
y
y
-
y
y
-
y
y
low power
Dolle 1989
Hox 11
expressed somewhere in the nephrogenic zone (low power)
KO no effect
Hsieh 1995
Gene
unind ub
duct tip
duct trunk
unind mm
blastema
cond-s
glom
neph
stroma
Remarks
References

HOX GENES NOT EXPRESSED

Gene
References
Hox B1 (2.9) Frohman 1990
Hox C10 (3.6) Peterson 1992
Hox D13 (4.8) Dolle 1991
Hox D1 (4.9) Frohman 1990
Hox 7 (Msx1) Robert 1989

 

HMG Box Genes and other Hox-like Genes

Gene
unind ub
duct tip
duct trunk
unind mm
blastema
cond-s
glom
neph
stroma
Remarks
References
brg-1 gamma
(y)
(y)
(y)
(y)
(y)
(y)
?
?
?
persists to adult
Randazzo 1994
EMX-1
located in some epithelial cells in the metanephros by in situ
-
Briata 1996
LEF-1
-
-
-
?
Y
surround
-
-
early
-
Oosterwegel 1993
LFB-1
?
n
n
n
n
Y(S)
n
Y
n
rat data
Lazzaro 1992
LFB-3
?y
y
y
n
n
Y
n
Y
n
rat data
Lazzaro 1992
LIM-1
-
Y
(y)
n
?
?y
?
Y
n

mesonephros data
KO blocks kidney devpt

Barnes 1994
Fujii 1994
Shawlot1995
Mox-1
?
n
n
Y
?y
n
n
n
n
-
Candia 1992
Pbx-1
-
-
-
-
?y
?y
-
-
-
definitely cortical
Roberts 1995
Sall1
-
-
-
Y
Y
-
-
-
-
-
Nishinakamura 2001
Six-2
-
n
n
-
Y
-
-
-
?
-
Oliver 1995
TCF-1
?
-
-
?
Y
surround
-
-
early
-
Oosterwegel 1993

GENES NOT EXPRESSED

Gene
References
eHAND Cserjesi 1995
Mox 2 Candia 1992
Phox 2 Valarche 1993
Cux Valarche 1993
Sox 2 Uwanogho 1995
Sox 3 Uwanogho 1995
Sox 11 Uwanogho 1995

 

Fox Genes

Gene
unind ub duct tip duct trunk unind mm blastema cond-s glom neph stroma Remarks
References
Foxc1
-
n
n
Y
y
y
n
n
n
see mutant table
Kume 2000
Foxc2
-
n
n
y
Y
y
n
n
n
see mutant table
Kume 2000
Foxd1
-
n
n
n
n
n
n
n
Y
see mutant table
Hatini 1993

 

Pax Genes

For more information on the general properties of Pax genes, visit the Pax gene database.

Gene
unind ub duct tip duct trunk unind mm blastema cond-s glom neph stroma Remarks
References
Pax 2
Y
Y
y
n
Y
Y
?
y
?n
antisense blocks devpt expression may be enough to trigger nephrogenesis.
see mutant table
Dressler 1992
Rothenpieler 1993
Dressler 1993
Dressler 1993
Pax 8
n
n
n
n
n
Y
y
y
n
-
Poleev 1992
Chalepakis 1992

GENES NOT EXPRESSED

Gene
References
Pax 1 Deutsch 1988
Pax 9 Neubuser 1995

 

POU Genes

Gene
unind ub duct tip duct trunk unind mm blastema cond-s glom neph stroma
Remarks
References
KDN-1
?
Y
?
n
n
n
n
n
?
-
Burrow 1993
POU 3f
expressed somewhere in adult mouse kidney (blot data)
mouse
Jehn 1994
POU 4
expressed somewhere in adult mouse kidney (blot data)
mouse
Andersen 1993
POU 6
expressed somewhere in adult mouse kidney (blot data)
mouse
Andersen 1993

 

Zinc Finger Genes

Gene
unind ub duct tip duct trunk unind mm blastema cond-s glom neph stroma Remarks
References
Brca-1
-
-
-
n
n
?
?
Y
n
-
Lane 1995
Evi-1
n
?Y
?Y
n
n
Y
?
Y
n
-
Perkins 1991
Glis2
-
Y
Y
n
n
n
n
n
n
-
Zhang 2002
KID-1
n
weak
weak
n
n
n
n
proximal
n
-
Witzgall 1998
Klf-6
Y
Y
Y
n
n
n
Y
n
n
-
Fisher 2001
WT-1
n
n
n
y
y
Y
Y
y
n
KO blocks devpt
see mutant table
Armstrong 1993

 

Miscellaneous Nuclear Proteins

Gene
unind ub duct tip duct trunk unind mm blastema cond-s glom neph stroma Remarks References
GATA-3
-
Y(man)
-
Y(man)
-
(y) (man)
-
-
-
-
-
-
Y
mesang
?
-
-
-
low res
human data
George 1994
Labastie 1995
c-myc
?
n
n
?
Y
Y
n
Y
n
-
Mugrauer 1991
L-myc
?
y
Y
?
Y
n
n
n
n
-
Mugrauer 1991
N-myc
?
n
n
?
Y
Y
n
n
n
KO causes varied
failiure of nephrogenesis
Mugrauer 1991
Stanton 1992
MFH-1
?
n
n
?
Y
Y
n
n
Y
around glom
-
Miura 1993
p53
?n
?n
?n
?
Y
Y
Y
y
-
weakens with maturity
see mutant table
Schmid 1991
TSC-22
-
?y
?y
n
Y
Y
n
n
n
-
Dohrmann 1999

GENES NOT EXPRESSED

Gene
References
Brachyury Kispert 1994

Date of last revision: January 2006
Comments about the database are always welcome.
Email:Jamie.Davies@ed.ac.uk